Product category: mAb, bispecific mAbs, peptides, Hormones, insulins, ADC, Fusion protein, Glyco protein
Primary structure analysis
- Intact Mass analysis- LC-MS
- Sub unit mass analysis- LC-MS
- Amino acid sequence verification -Reduced peptide mapping-LC-MS
Post Translational Modifications
# Mass spectrometry based Identification and quantification –LC-MS/MS -
MAM (Multi attribute monitoring method)
- Oxidation
- Deamidation
- Glycation
- Leader peptide
- Pyro glutamate
- Lysine variant
- Glycoforms
- N&C terminal integrity
- Sequence variants
And many more based on requirement
Secondary Structure analysis
- Circular Dichroism
- FTIR
Higher order structure analysis
- Disulphide mapping
- Circular dichroism
- DSC
- Fluorescence Spectroscopy
- NMR
Glycan identification and quantification
- UPLC-FLD
- LC-MS/MS
Charge and Purity:
Capillary Electrophoresis
1. Capillary isoelctro focusing (cIEF)
2. Imaged capillary electrophoresis (iCE)
3. CE SDS
Chromatography-HPLC/UPLC
1. Size exclusion chromatography (SEC)
2. Ion exchange chromatography (IEX)
3. Hydrophobic interaction chromatography (HIC)
Aggregation
- Analytical ultracentrifugation (AUC)
- Size exclusion HPLC- UV-MALS
- DLS
- LC-MS/MS